Meconium Aspiration Syndrome: Possible Pathophysiological Mechanisms and Future Potential Therapies
نویسندگان
چکیده
منابع مشابه
Meconium aspiration syndrome: possible pathophysiological mechanisms and future potential therapies.
Does meconium cause meconium aspiration syndrome (MAS) or is meconium discharge only a marker of fetal hypoxia? This dispute has lasted for centuries, but since the 1960s, detrimental effects of meconium itself on the lungs have been demonstrated in animal experiments. In clinical MAS, persistent pulmonary hypertension of the newborn is the leading cause of death in MAS. Regarding the complex c...
متن کاملMeconium aspiration syndrome in neonates
Perhaps the most significant changes in airway management over the recent years have been in the management of an infant delivered through meconium- stained amniotic fluid( MSAF). MSAF occurs in approximately 10℅ to 20℅ of all deliveries and increases to over 30℅ in deliveries after 42 weeks gestation. Meconium aspiration syndrome ( MAS) occurs in about 2℅ to 5℅ of these cases with a high morta...
متن کاملMeconium aspiration syndrome.
In the years 1977-82, 43 infants with the meconium aspiration syndrome (MAS) were managed at the Department of Paediatrics of Turku University Central Hospital (TUCH), Finland. Among 5,353 deliveries in one year the incidence of meconium staining was 8.7%. By extrapolation, the incidence of meconium aspiration in all newborns is approximately 0.13%. The mean duration of the pregnancies was 39.2...
متن کاملMeconium aspiration syndrome.
We agree that the passage of meconium in utero is not always due to intrauterine asphyxia and it may be a purely physiological event due to increasing maturity of the fetus. However, a bacterial endotoxin has been recently implicated in "causing the preterm labor and passage of meconium in utero(3). It is to be emphasized that only those neonates who have respiratory\distress with radiological ...
متن کاملN-acetylcysteine advancement of surfactant therapy in experimental meconium aspiration syndrome: possible mechanisms.
Meconium aspiration syndrome (MAS) is meconium-induced respiratory failure of newborns associated with activation of inflammatory and oxidative pathways. For severe MAS, exogenous surfactant treatment is used which improves respiratory functions but does not treat the inflammation. Oxidative process can lead to later surfactant inactivation; hence, surfactant combination with antioxidative agen...
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ژورنال
عنوان ژورنال: Neonatology
سال: 2015
ISSN: 1661-7800,1661-7819
DOI: 10.1159/000369373